Study of hypoglycemic effect of Fenugreek seed extracts

Trigonella foenum graecum (Fenugreek) is a popular herb widely used for culinary and pharmaceutical purposes. The seeds of the plant have been intensively studied, as they exhibit plenty pharmacological properties. objective current research was to investigate hypoglycemic effect fenugreek in vitro vivo. Aqueous (Aq. ex) ethyl acetate (ETAC. extracts were prepared from grinded seeds. α-amylase inhibitory activity assay evaluate vitro. Acarbose (the standard drug) positive control. While vivo glucose tolerance test assessed normal alloxan-induced diabetic mice. Glimepiride drug. Different concentrations both results suggested that ETAC. ex had significantly (P< 0.05) higher with IC50 106.39 µg/ml than Aq. = 159.55 µg/ml. However, it remained below acarbose (IC50 68.92 µg/ml) dose-dependent. In vivo, oral administration mice decreased rise blood levels (p< after 30, 60, 90 min compared which did not receive any treatment sometimes similarly treated Glimepiride. Thus, this study concludes may activity, being able moderately inhibit intestinal absorption possibly by other mechanisms.